What is the recommended dosage for tenecteplase in a patient undergoing mechanical thrombectomy for a large vessel occlusion?

The recommended dosage for tenecteplase in the context of a patient undergoing mechanical thrombectomy for a large vessel occlusion is based on factors such as the patient's weight and overall clinical guidelines. For tenecteplase, the dosage is typically calculated at 0.25 mg/kg, with a maximum of 15 mg for patients over a certain weight threshold.

In this specific scenario, a dose of 13.75 mg as an IV bolus aligns precisely with the recommended dosing strategy for many patients undergoing treatment for acute ischemic stroke where tenecteplase is indicated. This dosage option allows for an effective thrombolytic effect while acknowledging safety protocols and potential risks associated with thrombolytics.

This bolus dosage is supported by clinical trials that have examined tenecteplase's role in acute stroke therapy and its efficacy compared to other agents, contributing to making an informed decision regarding administration during mechanical thrombectomy.